Anti-interleukin 6 receptor antibody treatment in rheumatic disease.

بیماری استیل بالغین

Adult Still's Disease (ASD) is an uncommon systemic inflammatory disorder of unknown etiology and pathogenesis characterized by high quotidian fever accompanied by systemic manifestations. There is no single diagnostic test for AOSD diagnosis is often clinical, and it is always necessary to exclude common disease mimics such as infections, malignancies and other rheumatic diseases. Ferriti...

Optimal Treatment Strategy for Amyloid A Amyloidosis in Rheumatic Diseases – Anti-Interleukin-6 Receptor Therapy

Advances in interleukin 2 receptor targeted treatment.

T cell activation and cellular immune responses are modulated by interleukin 2 (IL2) through binding to its corresponding cell surface receptor. Three forms of the receptor are recognised based on IL2 binding affinity. The high affinity receptor is a heterotrimer composed of alpha, beta, and gamma(c)-polypeptide chains. The 55 kDa alpha-chain also known as the Tac (T cell activation) antigen or...

Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.

Campath 6, a rat IgG2b monoclonal antibody to the interleukin 2 receptor on activated T cells, was used to treat three patients with active rheumatoid arthritis unresponsive to conventional treatment. Two patients had an excellent response for about three months. There were no significant side effects. The results suggest that activated T cells are of importance in the pathogenesis of rheumatoi...

The correlations of serum interleukin-6 (il-6) levels and serum soluble il-6 receptor levels with disease activity in systemic juvenile idiopathic arthritis patients with and without tocilizumab treatment

Introduction Interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) have been demonstrated to play a significant role as inflammatory mediators in systemic juvenile idiopathic arthritis (SJIA). Tocilizumab, a humanized anti-IL-6 receptor antibody, becomes a new biologic treatment for SJIA nowadays but the correlation of serum IL-6 levels and serum sIL-6R levels with disease activity in SJIA wi...